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Risk of Type 2 Diabetes: Insulin resistance is a major precursor to the development of type 2 diabetes

Among the remaining patients, retention occurred in 67 of 780 patients (8.59%) in the BTX-A-only cohort, compared to 37 of 751 patients (4.93%) in the combination cohort

A series of opioid agonists, administered at doses that produce comparable analgesia acutely, further indicated that highly efficacious opioids tend to produce less tolerance following chronic administration than do less efficacious agonists (Stevens and Yaksh 1989

Based on current timelines: NDA submission Q4 2026, FDA review 1012 months, projected approval late 2027 under priority review or Q1 2028 under standard review

Liraglutides success for diabetes (approved 2010) spurred the quest for an even longer-acting version